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Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS
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Mechanistically, Epitalon’s effect appears to involve a direct interaction with promoter regions of the telomerase gene, where it binds specific DNA sequences (such as ATTTC motifs), potentially modulating transcriptional activity
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