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When it comes to CagriSema specifically, a clinical trial found that mild to moderate GI side effects were the most common (think: nausea, vomiting, and diarrhea), which were most likely to occur when the dose was increased

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The effects that PPIs exerted on PMNs and MΦs occurred due to the therapeutic mechanism of PPIs, the protonation of sulfhydryl groups, and the subsequent formation of a disulfide bond, while others occurred in the absence of protonation