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A former study displayed that genetic deletion of mitochondrial pyruvate carrier (MPC) encouraged CD8 T cell differentiation towards a memory phenotype and that MPC inhibition facilitated the production of Acetyl-CoA from glutamine and fatty acid oxidation, enhancing histone acetylation and further directing T cell differentiation (119)
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Size:25 Kilograms Jumbo
[DOI] [PubMed] [Google Scholar] 59.Giuliano F
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