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The gut mucosal barrier can separate the gut cavity from the internal environment of the body, avoid harmful substances such as bacteria and endotoxin in the gut cavity entering the body, and also block some drugs from entering the body to reduce the efficacy of drugs

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6,8 Athletes during those times sought to improve their performance in competition through diets unusually high in protein or through the consumption of stimulant substances such as brandy, wine, hallucinogenic mushrooms, and other stimulants that were usually extracted from natural sources, which helped them to overcome fatigue and thus improve their performance