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[2] Antioxidant enzymes, such as glutathione peroxidases and peroxiredoxins, generate glutathione disulfide during the reduction of peroxides such as hydrogen peroxide (H 2 O 2 ) and organic hydroperoxides (ROOH): [3] 2 GSH + ROOH → GSSG + ROH + H 2 O Other enzymes, such as glutaredoxins, generate glutathione disulfide through thiol-disulfide exchange with protein disulfide bonds or other low molecular mass compounds, such as coenzyme A disulfide or dehydroascorbic acid
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Certain foods and beverages can deplete glutathione levels
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