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In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD-deficient RBCs are ...
[49] In addition, CoA and acetyl-CoA, as well as NAD + and NADH, compete for binding sites on E 2 and E 3 , respectively, which catalyze reversible reactions
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