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GLP-1R agonists do not cause insulin secretion when blood glucose is low, which is why hypoglycemia risk is low compared to older diabetes medications
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By generating mice with astrocytic or hepatocytic ALDH2 deficiency, Jin and collaborators showed that acetate derived from central—rather than peripheral—ethanol metabolism primarily drove the synthesis of gamma-aminobutyric acid (GABA), the most common inhibitory neurotransmitter in the brain after low-dose ethanol administration
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