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Phase II pathways In the phase II reaction, the presence of transferase enzymes, drug metabolites byproduct from Phase I are enzymatically conjugated with glucuronidation, acetylation, and sulfation which are hydrophilic endogenous molecules that enhance the water solubility and facilitate the excretion of drug metabolites through Bile [11], [12]

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Enhanced markers of oxidative stress, altered antioxidants and NADPH‐oxidase activation in brains from Fragile X mental retardation 1‐deficient mice, a pathological model for Fragile X syndrome