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Type I collagenase prefers triple-helix collagen as its substrate, with cleavage sites at the N-terminus and C-terminus, while type II collagenase prefers substrates in descending order of affinity: peptides, denatured collagen, and triple-helix collagen, with preferred cleavage sites within the sequence
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The examination reveals point tenderness in the region of the epicondyle, and pain and weakness exacerbated by resisted wrist extension and supination for lateral epicondylitis, and with resisted wrist flexion and pronation for medial epicondylitis
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