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Normalization of Cd and protein excretion rates The urinary excretion of x (E x ) was normalized to creatinine clearance (C cr ) as E x /C cr = [Cd] u [cr] p /[cr] u , where x = Cd or pro, [x] u = urine concentration of x (mass/volume), [cr] p = plasma creatinine concentration (mg/dL), and [cr] u = urine creatinine concentration (mg/dL)