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Proteins 17 , 412–425 (1993)
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Cytokines such as IL-6, IL-10, and TGF-β produced by tumor cells in the TME hinder the activation of NK cells ( via a CCL1, CCL5-induced chemokine cascade that is disseminated by tumor cells, and CCL3 produced by TAMs is retained in the primary tumor ( Figure 3
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