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Activation of JNK then initiates a cascading effect, with translocation of phosphorylated JNK to the mitochondrial outer membrane58, where it binds with the Sab protein and initiates an Src-mediated inhibition of the electron transport and increases ROS production to amplify mitochondrial dysfunction61 and peroxynitrite formation59
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Background Interstitial cells and thin limb of Henlé cells from the disaggregated inner medulla have been purified in two steps
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