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These findings suggest that HSPHR incubation induces metabolic reprogramming in inflammatory chondrocytes, shifting energy production from glycolysis to OXPHOS, potentially linked to the activation of the chondrocyte PI3K-AKT-mTOR signaling pathway
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Discussion We demonstrated that decreases in GSH initiated a pathway that resulted in increased RhoU/Wrch1, which in turn led to a sequential increase in Hey2 expression and decrease in Sox17 expression (Fig
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