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In addition, Ahmadi and co-workers designed a smart nano system consisting of a magnetic inner core and polymeric outer shell with pH-responsive cationic cyclodextrin for targeted delivery and enhanced uptake of the anticancer drug methotrexate for the Saos-2 cell line [191]

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High concentrations of the substance accumulate in the: bones muscles brain liver kidneys Copper toxicity can lead to stomach pain nausea and vomiting diarrhea blue- or green-colored stool dark, sticky stool containing blood headache dizziness fatigue fever or chills aching muscles extreme thirst tachycardia or abnormally fast heart rate changes in taste that can lead to decreased appetite or anorexia Copper toxicity can also trigger the following neurological and psychological symptoms: sudden changes in mood symptoms of depression or anxiety feeling irritable or overexcited difficulty focusing Copper toxicity can have severe health effects, such as: kidney failure heart failure loss of red blood cells liver disease brain damage death Doctors can treat copper toxicity and other types of heavy metal poisoning with the following treatments: Zinc: Prevents copper from accumulating in the liver and gastrointestinal tract

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