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Along these lines, a significantand increasingamount of research has been dedicated to leveraging linkers to improve the pharmacokinetic profiles of radiopharmaceuticals, specifically increasing their target uptake and decreasing their background accretion and retention

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It is reported that pharmacological treatment of PD with DRT plausibly plays a role on glucose metabolism, with the finding that in animal model levodopa and DA can suppress glucose-dependent pancreatic islets secretion by reducing the frequency of intracellular calcium current oscillation, thus representing a DA-ergic negative feedback on insulin secretion (Ustione and Piston, 2012)