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Aging is accompanied by a gradual decline of NAD + concentration across multiple human tissues, including skin, blood, liver, muscle, and brain [[64], [65], [66], [67], [68], [69], [70]]
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after the initial intensive treatment phase, doctors typically transition the patient to maintenance strategies, such as daily sunscreen (absolutely essential), possibly a less potent lightening agent (azelaic acid or vitamin C), or other modalities, rather than keeping them on the hydroquinone/tretinoin/steroid continuously
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