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Some of the released molecules, referred to as damage-associated molecular patterns (DAMPs) like heme and its derivatives, ATP, heat shock protein (HSP70), or interleukin-33 (IL-33), are capable of triggering the immune response, amplifying inflammation [62, 63]

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After three decades of therapeutic experience, what has become clear is that potent immune modulators are highly effective at suppressing inflammatory relapses, yet exhibit very limited effects on the later progressive phase of MS