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Epigenetic changes in the hippocampus histone-H3 have been found to occur for the first days after a pediatric rat model of TBI, during the same time frame that the secondary injury of TBI is known to occur [52, 109]

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At the same time, the multifunctional nano-porphyrin material (P18-APBA-HA) constructed using photosensitizer-purpurin 18 (P18), hyaluronic acid, and 4-(aminomethyl)phenylboronic acid (APBA) can be inserted into the phospholipid membrane and loaded with epacadostat (EPA) to prepare a dual drug delivery system LipEPAP18-APBA-HA, which can also induce anti-tumor immunity by promoting DCs maturation, activating CD8 + T cells and inhibiting Tregs thereby suppressing tumor growth and metastasis (204)