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For patients aged 50 years and older, recommended screening should include age-appropriate investigations in accordance with prevailing clinical practice guidelines—such as colonoscopy for colorectal cancer, mammography for breast cancer, and cervical cytology or HPV testing as indicated
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Enhanced polyamine flux activation leads to elevated energy expenditure via polyamine acetylation, utilizing Acetyl-coenzyme A (acetyl-CoA) to generate acetylpolyamines (Jackson et al., 2003)
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