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The epigenetic changes at the CG locus were targeted by nuclear factor erythroid 2-related factor 2 (Nrf2) and activated NAD(P)H dehydrogenase quinone 1 (NQO1) and glutathione peroxidase 2 (GPX2)
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Limited by the available pool of these two scavenging proteins, patients experiencing severe hemolytic crises often exhibit undetectable levels of Hp and Hx in the blood, while free Hb and heme remain elevated (Saraf, 2020
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