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Heme accumulation in macrophage cytoplasms induces heme oxidase 1 which degrades heme into Fe2+, biliverdin, bilirubin, and carbon monoxide
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All of these share a commonality in that hormonal balances within the body shift through pregnancy, weight fluctuations (metabolic changes), and pregnancy - and really its the hormonal impact on collagen production that causes the skin to bounce back, or not
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