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In this context, estrogen/BDNF or estrogen/SIRT3 actions and interactions represent complex and fundamental mechanisms of neuronal plasticity, a process highly depending on energy supply via mitochondrial activity (Figure 4)

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Specialized IV therapies such as Niagen IV for brain and cognition support as well as fatigue, and Plaquex IV therapies for the support of liver and kidney disease and lowering of cholesterol are used daily at COEM to treat patients who travel locally and from a distance to receive expert care