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The inhibition of chemerin increases intracellular PUFA levels and decreases MUFA levels, leading to impaired mitochondrial respiratory chain function and CoQ10 and CIV down-regulation, resulting in more ROS generation and the induction of iron-mediated cell death (85)
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Primary skin fibroblasts from a 7-month-old and 8-year-old patients with TDD (at the time of collection) were used to generate TAN016 and TAN002 iPSC lines, respectively
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