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In addition, although the SREBP-1c–binding sequences in these promoters share some common bases, the exact sequences vary hugely (49), which may also contribute to different binding affinity and different regulatory pattern
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55 These mutations can be maternally inherited, and it is estimated that nearly 2473 women in the UK and 12,423 women in the US, aged 15 to 44, carry pathogenic mtDNA mutations
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