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In oxaliplatin-induced CIPN models, melatonin prevented the loss of mitochondrial membrane potential (Ψm), promoted nerve regeneration in oxaliplatin-challenged Neuro-2a cells and prevented the loss of nitrosation of proteins and antioxidant enzymes by improving nitrooxidative stress mediated by the chemotherapeutic agent oxaliplatin [45] without interfering with oxaliplatin cytotoxic activity in human colon cancer cell lines
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Because FDA evaluated the free-base and acetate forms separately, its materials presented fourteen individual proposals, each recommending that the applicable form not be included on the 503A Bulks List
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