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H2: The Pathways Are Different GHK-Cu activity in research models has been most frequently linked to: Matrix metalloproteinase (MMP) / TIMP balance in extracellular matrix studies Antioxidant response elements and Nrf2 pathway signaling TGF-beta signaling in fibroblast cultures Copper delivery to cuproenzymes such as lysyl oxidase KPV activity has been most frequently linked to: NF-kB pathway modulation Downstream cytokine output (TNF-alpha, IL-6, IL-1beta) Mast cell mediator release Intestinal epithelial inflammation markers (via PepT1-mediated uptake) These two lists do not overlap meaningfully
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