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Indeed, several guanine nucleotide exchange factors (GEFs) and GAPs that regulate the nucleotide status of the Rag GTPases have already been identified, with the most notable GEF being the Ragulator complex [52,59] and with GAPs including the GAP activity towards the Rags (GATOR) 1 complex (towards RagA/B) [55], the tumour suppressor folliculin (FLCN) in complex with FLCN-interacting protein 1/2 (towards RagC/D) [60] and leucyl tRNA synthetase (towards RagD) [44,61]
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