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However, aging or chronic pathology induces myelin debris overload exceeding microglial clearance capacity, leading to lipid droplet (LD) formation and mitochondrial dysfunction that drive pro-inflammatory polarization (85,86)
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Finally, publicly available snRNA-seq data 35 were integrated with our data, showing that signalling-related proteoforms linked to cognitive resilience may localise to inhibitory SST-INs, whereas cytoskeletal proteoforms linked to frailty may be enriched in excitatory IT populations (Figs
is made up of highly conserved domains such as two Rossmann fold domains
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