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In studies of Hepatocellular Carcinoma (HCC), SUMOylation enhances the ability of NRF2 to scavenge ROS and upregulate PHGDH, promoting de novo serine synthesis
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It can be also transported beyond the site of synthesis, acting as a signaling molecule and mediating systemic acquired resistance (SAR) - a whole-plant resistance response that prepares plant for another infection [40]
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