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Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into Ξ±-ketoglutarate (Ξ±-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]
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Consider whether an acceptable alternative could meet the same purpose. Avoid allowing a short deadline to erase an essential requirement.
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