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Preferably, such a composition of the invention for use as a modulator of the TRPM8 receptor, preferably for use in a therapeutic method of modulating the TRPM8 receptor, additionally comprises: (1) one or more further substances having physiological cooling action, wherein the further substance or one, more than one or all of the further substances (i) cause(s) a flavoring effect or (ii) do(es) not cause a flavoring effect, and/or (2) one or more aromas with no physiological cooling effect and/or (3) one or more substances having a trigeminal or mouthwatering effect with no physiological cooling effect and/or (4) (iii) one compound or (iv) two or more compounds which, independently or collectively in case (iv), additionally cause(s) a flavor-modulating effect and/or a trigeminal and/or mouthwatering stimulus

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Researchers should establish an appropriate experimental protocol before preparation and confirm that all selected solvents, materials, and analytical methods are compatible with the intended study

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