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FIGURE 2 Recent studies have shown that accumulation of leucine in GC activate the mTOR pathway by downregulating BCAT2 expression ( In summary, BCAT1 acts as an oncogenic driver in GC through multiple pathways, including PI3K/AKT/mTOR activation, the promotion of angiogenesis, and mutation-mediated RhoC signalling, whereas BCAT2 exerts tumor-suppressive effects, indicating isoform-specific roles that may guide the development of targeted therapy
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HPLC separation of the MDA-(TBA)₂ adduct can improve specificity by reducing interference from non-MDA TBARS
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