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The ability of ASXL1 1-645 to engage with BRD4 and MLL3/4 may help in the recruitment to or stabilization of the BAP1 complex at specific genomic regions, i.e., at H3K4me3-rich active promoters through binding of BRD4, and at H3K4me1-rich active enhancers through binding of MLL4 10,38 (Fig