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Following this clear dichotomy, we designed studies to provide evidence of the causal relationship between the gut microbiome, PAGln accumulation, and aberrant cardiovascular physiology independent of direct alcohol exposure

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The complex interaction relationship between iron metabolism disorders and changes in the abundance of gut microbiota (especially Bifidobacterium ) revealed in this section provides evidence for clarifying the molecular mechanism of the hypothetical pathological axis of “iron overload-disruption of gut homeostasis-ferroptosis in OA,” and suggests that targeted regulation of the iron-microbiota interaction may become a potential new strategy for the prevention and treatment of OA