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Of these mRNAs, perhaps most important is ATF4, a transcription factor that binds DNA targets to regulate gene expression, essential for restoring mitochondrial homeostasis [228]
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At physiological levels, BCAAs enhance CD8 + T cell antitumor activity via FoxO1-mediated glucose transporter 1 (GLUT1) upregulation, facilitating glycolytic-oxidative phosphorylation coupling (Yao et al., 2023)
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