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*Correspondence: Patrik Krumpolec, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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To examine the capacity of WT and Mda5 -/- HSCs to repopulate lethally irradiated recipients, we sorted and transplanted 100 LSK-SLAM HSCs from young or aged WT or Mda5 -/- mice together with aged-matched CD45.1 competitors into CD45.1 lethally irradiated recipients, followed by whole bone marrow competitive secondary transplantations
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