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According to its role as a master regulator of cell growth, mTORC1 activity is modulated by different extracellular signals and intracellular mechanisms, interestingly it has been shown that some miRNAs can also regulate the mTORC1 activity directly or through targeting upstream regulators such as PI3K/Akt pathway
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In second‐line, ramucirumab, alone or in combination with paclitaxel, demonstrated significant survival benefits
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