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IOP1 may acts as a CIA adapter protein, mediating the contact between early and late parts of the CIA machinery, although the exact mechanism is still under discussion (see Figure 1) [47,58,59]
In-Vitro Research
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Pathological myelin overload exceeding lysosomal degradation capacity induces lysosomal damage, triggering microglial senescence and pro-inflammatory cytokine release-termed the senescence-associated secretory phenotype (SASP) (85)
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