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The rationale for combining these peptides extends beyond simple additive effects, as BPC-157's gastric pentadecapeptide sequence activates growth factor pathways and nitric oxide systems while TB-500's thymosin beta-4 derivative promotes actin regulation, cell migration, and blood vessel formation through separate receptor interactions
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[DOI] [PubMed] [Google Scholar] [143].Jessup SK, Dimaraki EV, Symons KV, Barkan AL, Sexual dimorphism of growth hormone (GH) regulation in humans: endogenous GH-releasing hormone maintains basal GH in women but not in men, J Clin Endocrinol Metab 88(10) (2003) 4776–80
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