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however, no clinical trials have been conducted with N-acetylcysteine, which constitutes a “thiol” compound and acts as a donor of L-cysteine, leading to replacement and increased levels of intracellular glutathione.2, 4, 5, 6 The objective of this study was to evaluate the effectiveness of using oral N-acetylcysteine for eight weeks in the treatment of facial melasma in adult women
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For example, in the liver, oxidants lead to a marked increase in biliary GSSG excretion, with GSSG concentrations in bile usually exceeding those in hepatocytes, indicating an active canalicular membrane transport process (Keppler et al., 1997
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