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GRP78, a central sensor of the UPR, binds unfolded proteins via its N-terminal domain and interacts with UPR signaling branches through its C-terminal domain, maintaining these pathways in an inactive state under basal conditions (Liang et al., 2025)
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Consider whether an acceptable alternative could meet the same purpose. Avoid allowing a short deadline to erase an essential requirement.
Use a cropped view when it fully supports your intended point. Keep enough context to avoid misrepresenting the information shown.
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