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Yet, when sporadic AD occurs, the balance between the non-amyloidogenic and the amyloidogenic pathway becomes altered and, there is an excessive production of Aβ, resulting from the cleavage of AβPP by the β- and γ -secretase enzymes and a lower degradation of Aβ due to a lower activity of the degrading enzymes previously mentioned, thus causing an imbalance between the production and elimination of Aβ [33–40]