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For the case of such a small molecule as niclosamide, (V m = 202.5±3.0 cm 3 , ACD/iLabs) and a low topological polar surface area of 95.15Å 2 (Drugbank), (where any value below 140Å 2 is considered hydrophobic enough to partition into the membrane interior), it is well within the parameters for membrane partitioning
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1 - 13 The data so far presented suggested that BPC 157 may modulate NO-system effect, providing that its effectiveness could override the effects of NOS-blockade (induced by NOS-blocker L-NAME), NOS-overstimulation (induced by NOS-substrate L-arginine application), or NOS-system immobilization (induced by simultaneous administration of L-NAME and L-arginine)
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