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Pharmacological options for managing overt hepatic encephalopathy Abbreviations BCAAs branched-chain amino acids BRTO balloon-occluded retrograde transvenous obliteration cACLD compensated advanced chronic liver disease CFF critical flicker frequency CHE covert hepatic encephalopathy CLDQ Chronic Liver Disease Questionnaire CPG clinical practice guideline EIS endoscopic injection sclerotherapy EVL endoscopic variceal ligation EVO endoscopic variceal obturation GRADE Grading of Recommendations HRQoL health-related quality of life HVPG hepatic venous pressure gradient ISHEN International Society for Hepatic Encephalopathy and Nitrogen Metabolism KASL the Korean Association for the Study of the Liver KPPT Korean paper and pencil test LDQoL Liver Disease Quality of Life LDSI Liver Disease Symptom Index MHE minimal hepatic encephalopathy MRI magnetic resonance imaging NHP Nottingham Health Profile NSBBs nonselective beta-blockers OHE overt hepatic encephalopathy PARTO vascular plug-assisted retrograde transvenous obliteration PCS physical component summary PHES psychometric hepatic encephalopathy score RCTs randomized controlled trials SDMT symbol digit modality test SF-36 Medical Outcomes Study Short Form-36 SF-LDQOL Short Form Liver Disease Quality of Life SVR sustained virologic response TIPS transjugular intrahepatic portosystemic shunt REFERENCES 1