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These studies highlighted reduced expression and inhibition of HIF-1α activity and subsequent reductions in expression of key glycolytic enzymes (e.g., Glut1, PDK, pyruvate kinase M2 [PKM2], lactate dehydrogenase a [LDH], and hexokinases) as major drivers of this metabolic plasticity (179, 180, 182)
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The effect of HIF on metabolism and immunity
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