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Furthermore, under OA-related inflammatory and metabolic stress environments, cells may promote GPX4 ubiquitination and subsequent proteasomal degradation by inducing specific E3 ubiquitin ligase activity, thereby increasing cellular susceptibility to ferroptosis (Su et al., 2025
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and, R5 is selected from the group consisting of H, phenyl, CH 3 - and CH 2 -phenyl
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