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In this metabolism, a carbon unit from serine or glycine is transferred to tetrahydrofolate (THF) to form 5,10-methylene-THF
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In addition to glutamate and cysteine, GSH synthesis depends on the availability of glycine, which is an amino acid required for many metabolic processes, including the synthesis of purines (e.g., adenine, guanine) in rapidly dividing tumor cells
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