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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters — establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions
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This protonates the amino acid side chains, increasing their polarity and forcing the peptide to dissolve completely
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