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PEGylated LPs are an alternative strategy due to the protection afforded by non-specific plasma protein absorption and its uptake in the reticuloendothelial system, resulting in extended systemic circulation and improved biodistribution in the brain

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Some produced amines are bio-active molecules (histamine, tyramine, triptamine, beta-phenylethyl amine, GABA), acting at vascular or central nervous system level of human host (Moreno-Arribas et al., 2003), while others are informational messengers for microbial cross-talk and for stress control (at least for putrescine in some bacterial species)