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Abbreviations ALT Alanine aminotransferase AST Aspartate aminotransferase BMI Body mass index CAP Controlled attenuation parameter FBS Fasting blood sugar HbA1c hemoglobin A1c HDL High-density lipoprotein IRI Immunoreactive insulin LDL Low-density lipoprotein LSM Liver stiffness measurement NAFLD Nonalcoholic fatty liver disease NASH Nonalcoholic steatohepatitis NEFA Non-esterified fatty acid UMIN University Hospital Medical Information Network VCTE Vibration-controlled transient elastography Authors’ contributions Designed and coordinated the study: TK, YH, YS, and AN

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Further, while the mimetics include certain N-acyl groups as specified in Table 1 (Family 1), in the practice of various embodiments of the invention other N-acyl groups or substituted or unsubstituted phenyl groups may be used at R 2 and R 3 , respectively, a wide range of amino acid and other residues might be used for the mimetics or agonists ( 1

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